Previous studies have shown that TGF-βRII-deficient mice could effectively resist PF caused by bleomycin (Li et al., 2011), supporting that as a receptor necessary for TGF-β1 signaling, TGF-βRII is essential for the development of PF (Li et al., 2011; Zhang et al., 2017). The gene discussed is TGFB1; the disease is pemphigus foliaceus.