NLRP3 and head and neck squamous cell carcinoma: Recently, researchers also focused on contributing chronic inflammation created by NLRP3 activation to carcinogenesis, including proliferation, angiogenesis, immunosuppression, and metastasis Liu et al. (2021), Huang et al. (2017), and Chen et al. (2018) showed that blockage of the NLRP3 inflammasome could enhance the antitumor immune responses in head and neck squamous cell carcinoma, suggesting that the NLRP3 inflammasome pathway may be regarded as a novel approach for the treatment of head and neck squamous cell carcinoma.