The multivariate analysis further confirmed the independent prognostic value of NLRP3 protein overexpression for PFS (hazard ratio (HR) = 2.92, p = 0.002, C-index = 0.70) and OS (HR = 4.09, p = 0.017, C-index = 0.79) in osteosarcoma patients (Table 3). The gene discussed is NLRP3; the disease is osteosarcoma.