Epidermal growth factor receptor (EGFR), a tyrosine kinases receptor (RTK) of ErbB family, is over-expressed in some cancers (Salomon et al., 1995; Mendelsohn and Baselga, 2000), including esophageal squamous cell carcinoma (ESCC) (Hanawa et al., 2006; Wang et al., 2013; Shang et al., 2014). Here, EGFR is linked to esophageal squamous cell carcinoma.