IL6 and neoplasm of esophagus: The mice with IL-6 stimulation showed significantly increased myeloid derived suppressor cells (MDSCs) levels and an increased incidence of invasive esophageal tumor formation in the 4NQO-induced esophageal tumor animal model; however, blockade of IL-6 prevented induction of MDSCs and the incidence of 4NQO-induced invasive tumors (Chen et al., 2014).