Puerarin acts on the circadian protein REV-ERBα (whose expression oscillates with times of the day with a higher level at ZT10 and a lower level at ZT2) as an antagonist to increase hepatic expressions of three key enzymes involved in homocysteine catabolism (i.e., BHMT, CBS, and CTH), thereby alleviating hyperhomocysteinemia in mice (Chen et al., 2020; Zhang et al., 2019). The gene discussed is CBS; the disease is hyperhomocysteinemia.