NR1D1 and hyperhomocysteinemia: In our previous studies, puerarin (a main active constituent of PR) acts on the circadian protein REV-ERBα as an antagonist to alleviate hyperhomocysteinemia, whereas berberine (a main active constituent of CR) acts on REV-ERBα as an agonist to attenuate chronic colitis (Chen et al., 2020; Zhou et al., 2020).