Stimulation of antioxidant Nrf2/HO-1 signaling by cobalt protoporphyrin IX (CoPP), a HO-1 inductor, and sulforaphane potentiated the antiallodynic effects of JWH133 and could be beneficial for the treatment of T2DM-associated neuropathic pain. Here, HMOX1 is linked to type 2 diabetes mellitus.