CASP1 and obesity due to melanocortin 4 receptor deficiency: The NLRP3 inflammasome (NLRP3/ASC/caspase-1 complex) is a key player of inflammation and M1 macrophage polarization (Ślusarczyk et al., 2018), and plays a central role in the induction of obesity and IR (Stienstra et al., 2011; Vandanmagsar et al., 2011).