These findings were associated with attenuated phosphorylation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) (the key proteins in MAPK signaling pathway) in eWAT of diet-induced obesity (DIO) mice (Figure 3B). The gene discussed is MAPK8; the disease is obesity due to melanocortin 4 receptor deficiency.