AKT1 and rheumatoid arthritis: Series of signaling pathways were reported to be referred to in the occurrence and development of RA, such as the JAK/STAT pathway which regulates the gene expression of matrix metalloproteinases of inflamed synovial tissues (Malemud et al., 2018), PI3K/AKT/mTOR pathway which regulates the cell cycle, cellular quiescence and proliferation (King et al., 2015; Feng et al., 2018), MAPK pathway which regulates the production of proinflammatory cytokines (Yang et al., 2018; Thalhamer, et al., 2008), and so on.