TNF and rheumatoid arthritis: Furthermore, 45 signaling pathways were identified through KEGG pathway enrichment analysis (Supplementary Table S5), and the top 20 signaling pathways were represented as a bar graph (Figure 9D), among which, PI3K-Akt pathway, MAPK pathway, Ras pathway, HIF-1 pathway, TNF pathway, Chemokine pathway, IL-17 pathway, FoxO pathway, Rap1 pathway, AGE-RAGE signaling pathway in diabetic complications had been proved associated with the treatment of RA.