The top 10 signaling pathways firmly related to RA therapy were PI3K-Akt pathway, MAPK pathway, AGE-RAGE signaling pathway in diabetic complications, Ras pathway, HIF-1 pathway, TNF pathway, Chemokine pathway, IL-17 pathway, FoxO pathway, Rap1 pathway. The gene discussed is RENBP; the disease is rheumatoid arthritis.