Series of anti-RA drugs used in the clinic, such as methotrexate, inhibitors of Janus kinase (JAK), and tumor necrosis factor (TNF), would induce nonnegligible side-effects such as cytopenia, transaminase elevation, cardiovascular disease (CV), and gastrointestinal (GI) events (Walsem et al., 2015; Burmester et al., 2017; Chatzidionysiou et al., 2017). This evidence concerns the gene TNF and rheumatoid arthritis.