The RAAS has wide-ranging effects on blood pressure regulation, mediating vasoconstriction, endothelial dysfunction, and vascular injury through its most pharmacological factor angiotensin II (AngII) binding with its receptor, that is, AngII type I receptor (AT1R) (Gasc et al., 1994; Garg and Yusuf, 1995; Touyz 2005; Montezano et al., 2014). Here, AGT is linked to endothelial dysfunction.