The etiology of hypertension involves a complex interplay of various elements, including genetic, neurohumoral, and environmental factors, among which the renin-angiotensin-aldosterone system (RAAS) plays a critical role in the pathogenesis of hypertension (Elliott 2007; Fujii et al., 2007; Oparil et al., 2018). Here, REN is linked to hypertensive disorder.