ACHE and Alzheimer disease: The main drugs used for AD treatment are AChE inhibitors such as donepezil, galantamine, and tacrine, which reduce extrasynaptic metabolism of ACh and thereby enhance its concentration at the synaptic cleft Ionita et al. (2018); and N-methyl-d-aspartic acid glutamate receptor antagonists such as memantine (Tayeb et al., 2012).