Several recent studies have shown that isothiocyanates obtained from cruciferous plants can be effective in reducing the risk of many cancers as they can cause chemopreventive effects by involving various signaling pathways (Popolo et al., 2017; Abbaoui et al., 2018; Pan et al., 2018; Zhang et al., 2018).Previously, the effect of phenethyl isothiocyanate on KB and HEp-2 indicated growth inhibition and apoptosis induction, exhibited through death receptors 4 and 5(Huong et al., 2011). This evidence concerns the gene TNFRSF10A and cancer.