On the other hand, female mice have been shown to exhibit more consistent pronounced inflammatory response than male mice with elevated levels of CD4+ T-cells and relevant proinflammatory cytokine, and thereby are more widely used in animal models of allergic diseases, like asthma, atopic dermatitis, and allergic rhinitis (Melgert et al., 2005). The gene discussed is CD4; the disease is atopic eczema.