INS and Insulin resistance: The combination of western diet and amyloid pathology resulted in significant increases in the circulating levels of insulin (3.8-fold, P < 0.001), triglycerides (2.8-fold, P < 0.001), CRP (2.0-fold, P < 0.01), and IL-1β (3.0-fold, P < 0.01) as compared to wild type mice fed standard diet (Figure 1A), suggesting diet-induced exacerbation of insulin resistance and inflammation.