Six of 346 patients with suspected CJD revealed neural surface autoantibodies NMDAR, CASPR2, LGI1, aquaporin 4, Tr [DNER (δ/notch-like epidermal growth factor-related receptor)], although those six patients failed to fulfill the criteria for possible or probable CJD. The gene discussed is CNTNAP2; the disease is Creutzfeldt Jacob disease.