While this may suggest age-dependent cognitive impairment in GFAP-IL6 mice, we also observed a trend for reduced speed during acquisition in GFAP-IL6 mice at 22 months and reduced distance traveled at probe irrespective of age, indicating some locomotor impairment in these mice, similar to that reported previously in these mice from 6 months of age onward (Gyengesi et al., 2019). This evidence concerns the gene IL6 and Cognitive impairment.