Accumulation of Aβ and tau results from an imbalance between its production and clearance, which is the key histopathological hallmark of Alzheimer’s disease, and a defective clearance system can be a possible candidate to explain Alzheimer’s disease development and Aβ accumulation (Verheggen et al., 2018). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.