BPI and acute respiratory distress syndrome: For instance, Kangelaris et al. found that the important mediators of the initial neutrophil response to infection, including olfactomedin 4, lipocalin 2, CD24, and bactericidal/permeability-increasing protein were obviously and differentially expressed between patients with sepsis complicated with ARDS and patients with sepsis alone, suggesting that these genes were potentially associated with the pathogenesis of ARDS related to sepsis [10].