HIF1A and pneumonia: Therefore, we here aimed to study the role of myeloid cell HIF1α in the host defense during pneumonia-derived sepsis using a well-established model via low-dose infection with K. pneumoniae via the airways [17–19], resulting in a gradually growing bacterial load in the lungs with subsequent dissemination and sepsis, allowing analyses of both early protective and late injurious responses associated with innate immune activation.