CCN3 and chronic myelogenous leukemia, BCR-ABL1 positive: These observations suggested that CCN3 was associated with cancer staging and prognosis as well as contributing to tumorigenesis or metastasis formation On the other hand, CCN3 can also negatively regulate some other kinds of tumor growth, such as melanoma, glioblastoma, and chronic myeloid leukemia [42, 48, 49].