Although it was later found that CCN3 did not have a noticeable effect to attenuate the liver fibrosis due to hepatocyte apoptosis which occurred simultaneously [38], the correlations between CCN3 and antifibrosis actions have been identified in a variety of diseases such as chronic overuse muscle fibrosis, glomerular and tubulointerstitial renal fibrosis, and systemic sclerosis [24, 39–41]. This evidence concerns the gene CCN3 and systemic sclerosis.