CCN3 and obesity due to melanocortin 4 receptor deficiency: Recent investigation shows that serum CCN3 correlated positively with adiposity-related parameters and insulin resistance indices, which is the first study to focus on the serum concentration of CCN3 in newly diagnosed T2MD (nT2MD) in humans [64], and a strong relationship between plasma CCN3 and obesity was also detected by measuring hundreds of adults suffering from hyperlipidemia and/or receiving lipid-lowering treatment and/or having a high BMI (>30 kg/m2) [65].