The majority of the identified ARVC variants, classified as pathogenic or unknown in the disease genetic variant database, are in five most commonly mutated desmosomal protein genes: plakoglobin (JUP), desmoplakin (DSP), plakophilin-2 (PKP2), desmoglein (DSG2) and desmocollin-2 (DSC2) [5]. Here, DSC2 is linked to arrhythmogenic right ventricular cardiomyopathy.