VEGFA and neoplasm: For various reasons, the VEGF pathway is a good target for anti-angiogenic therapy, suchas: it is generated by growing primary tumours in large quantities; the VEGF pathway induces the production of sprouting blood vessels [6]; the VEGF pathway binds to endothelial cells involved in the formation of bloodvessels; the endothelial cells are also genetically stable and spontaneous mutations are rare compared to unstressed mutations.