Another systematicreview and meta-analysis revealed no increased risk of cancer [overall] inpatients with psoriasis treated with biologic agents.53 Interestingly, data from other chronic inflammatory conditions suchas rheumatoid arthritis and inflammatory bowel disease studies are notentirely conclusive regarding the risk of melanoma with systemic or biologictreatment, including TNF-α inhibitors.54, , , -58. The gene discussed is TNF; the disease is melanoma.