Myeloid cells derived from bone marrow contribute to the formation of the premetastatic microenvironment[42] and persistent production of immune response‐related cytokines in tumor cells increases MDSCs recruitment, resulting in the promotion of CSC properties, cancer immune escape, and metastasis.[7, 24, 43] Thus, we investigate whether upregulation of IL‐6, IL‐22, and TNFα by the KAT6A–SMAD3 axis described above is critical for breast cancer stem‐like cell (BCSC) properties in TNBC. This evidence concerns the gene TNF and cancer.