The biological functions of SMAD3 are modulated by its binding partners.[33, 34] TRIM33 is a member of the tripartite motif (TRIM) protein family and is recruited to SMAD3, leading to transcription inhibition of SMAD3 targeted genes.[35] TRIM24 is a TRIM33 related cofactor in TRIM superfamily[36] and a reader protein of KAT6A‐mediated H3K23ac in cancers.[10, 37, 38] Thus, we investigated whether the K20/117 acetylation impacts SMAD3 association with TRIM33 and/or TRIM24. This evidence concerns the gene SMAD3 and cancer.