KAT6A and breast cancer: Early studies have revealed that KAT6A gene fusions resulting from chromosome translocation causes preleukemia stem cell transformation.[16, 17, 18] Increasing data demonstrate that KAT6A also regulates tumor progression.[10, 14] KAT6A amplification and/or overexpression in luminal subtype breast cancers promoted tumor growth.[15, 20] However, the mechanism by which KAT6A drives breast cancer progression is still elusive.