Consistent with the above observations, ectopic expression of the SMAD3‐2KQ mutant promoted tumor growth (Figure S8E,F, Supporting Information), lung metastasis (Figure S8G, Supporting Information), reduced survival of 4T1 tumor xenograft bearing animals (Figure S8H, Supporting Information), and promoted MDSCs accumulation (Figure S8I, Supporting Information), CD4+ and CD8+ T cell depletion (Figure S8J,K, Supporting Information) whereas it did not affect macrophage recruitment and the infiltration of B cells and NK cells (Figure S8L–N, Supporting Information). The gene discussed is CD4; the disease is neoplasm.