SMAD3 acetylation was implicated in pulmonary fibrosis, tumor progression, and gene expression.[27, 28, 54] The present study not only corroborates KAT6A acetylated nonhistone protein SMAD3 but also presents additional findings on the role of acetylated SMAD3 in MDSCs recruitment and cancer metastasis.[27, 28, 54] In addition, we identify only KAT6A, but not other KATs, as an acetyltransferase for SMAD3. This evidence concerns the gene KAT6A and cancer.