IL10 and acute myeloid leukemia: Overall, even though the ligand-based IL-10 CAR-T cells led to potential immunosuppressive effects on TME, we still demonstrated that IL-10R is a potential target for AML since IL-10R targeted CAR-T therapy displayed significant anti-AML effects both in vitro and in vivo, and it displayed little cytotoxicity on normal hematopoietic cells.