To verify it, the expression of IL-10RA and IL-10RB on other kinds of tumor cell lines including Burkitt lymphoma (Raji, Daudi), ALL (Nalm-6), multiple myeloma (H929, MM1.S) (Supplementary Fig. 5a, b) was analyzed, and IL-10 CAR-T exhibited obvious cytotoxicity towards these cell lines (Supplementary Fig. 5c). This evidence concerns the gene IL10 and acute lymphoblastic leukemia.