Analysis of endogenous immune infiltrates revealed there were no differences of monocytic myeloid-derived suppressor cells (M-MDSC); polymorphonuclear (PMN) MDSC; tumor-associated macrophage (TAM) between the mVEC-T group and mIL10-CD28 or mIL10-4-1BB CAR-T groups. The gene discussed is CD28; the disease is neoplasm.