EGFR and lung adenocarcinoma: Somatic mutations were identified using WES of tumor and germ line DNA; as expected, EGFR-mutant lung adenocarcinoma patient NCI-RA007 had much fewer somatic mutations (289) compared with the melanoma patient–derived cell lines, NCI-3784Mel and NCI-3795Mel (2678 and 2031, respectively) (supplemental Fig. S1C and supplemental Table S2).