PTPA and cancer: Indeed, proline-rich coiled-coil 2C (PRRC2C)p.M2171I and secernin 2 (SCRN2)p.M323V were exclusively discovered in lung cancer; importantly, cellular inhibitor of PP2A (CIP2A)p.R229Q (legacy identifier: COSM3759596) has been confirmed as a somatic mutation in multiple cancers (i.e., lung, blood, pancreas, and colon) according to COSMIC DB (Fig. 2C).