IL4 and immunoglobulin G4-related sclerosing disease: To clarify whether Th2 cytokines and the CCL8–CCR8 axis are upregulated in LAT mice as they are in IgG4-RD patients, we compared Il4, Il10, Ccl8, and Ccr8 mRNA expressions in the spleen, cLNs, and SGs of the LAT mice and the littermates.