In particular, CSS suppressed the ratio of inflammatory γ-Proteobacteria to antiinflammatory Lactobacillaceae can decrease the expression of proinflammatory cytokines in the gut through the suppression of NF-κB activation, resulting in the alleviation of depression through the attenuation of systemic inflammation including neuroinflammation. The gene discussed is NFKB1; the disease is major depressive disorder.