To enhance the tumor accumulation of the vector based on the high expression of the CD44 protein in human non-small cell lung cancer cells (A549), hyaluronic acid (HA), a natural receptor for CD44 that exerts good biocompatibility, biodegradability, and non-immunogenicity properties, was selected to hybridize RBCm (HA&RBCm) [23–25]. This evidence concerns the gene CD44 and neoplasm.