In the present study, we examined the molecular mechanism underlying the apoptotic cytotoxicity following treatment with the ethanol extract of P. kaempferi (EEPK), which was associated with the Mcl-1 inhibition in human mucoepidermoid carcinoma (MEC) cells caused by translation inhibition and proteasome-mediated degradation. The gene discussed is MCL1; the disease is mucoepidermoid carcinoma.