Among the identified pathways, several pathways were well established in cancers, including small cell lung cancer, pathways in cancer, thyroid cancer, P53 signaling pathway, and WNT signaling pathway; all of these pathways promote the development of tumours, indicating that these pathways were active in high-risk patients, while other pathways were silent in high-risk patients. Here, TP53 is linked to thyroid gland carcinoma.