After the second vaccination, all test subjects demonstrated IFN-γ release upon pepS stimulation, whereas co-incubation with the nucleocapsid peptide pools (pepN) resulted almost exclusively in an IFN-γ release in subjects that had recovered from COVID-19 (1•1 [95% CI 0•3–4•0] pg/mL vs. 732•3 [95% CI 450•0–1192•0) pg/mL], t-test p<0•0001; Fig. 2a). This evidence concerns the gene IFNG and COVID-19.