Based on the in silico analyses, the SUMOylation state of the endogenous TDP-43 protein was then assessed in vitro by immunoprecipitation (IP) of human neuroblastoma SK-N-BE cell lysates with two different antibodies recognizing aminoacidic sequences at the N-terminal or at the C-terminal region of TDP-43. Here, TARDBP is linked to neuroblastoma.