Since a negative modulation of SUMOylation by the cell-permeable peptide TS-1 induced a redistribution of TDP-43 in the cytoplasm, we further investigated if this had also an impact on the sub-cellular localization and aggregation of the pathological C-terminal TDP-43 fragments, p35 and p25, detected in ALS/FTD post-mortem brains. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.