By analysing the sub-cellular distribution of TDP-43 in human neuroblastoma SK-N-BE cells exposed to sodium arsenite (0.5 mM) for 30 min, we observed that the TDP-43 K136R protein remained in the nucleus, while the wild-type TDP-43 formed cytoplasmic foci co-localizing with the SG marker TIAR, as expected (Fig. 4a). The gene discussed is TARDBP; the disease is neuroblastoma.