TARDBP and amyotrophic lateral sclerosis: Therefore, our findings, by showing that TDP-43 sub-cellular localization in the cytoplasm may be regulated also by SUMOylation, help uncover all the molecular mechanisms causing TDP-43 cytoplasmic mislocalization as the initial event for its pathological aggregation in ALS/FTD and might be used to better define possible druggable targets.