THBS1 and cancer: Many soluble extracellular glycoprotein ligands such as decorin (DCN), thrombospondin 1 (THBS1), biglycan (BGN), endostatin (COL18A1), collagen VI and plasminogen kringle 5 activate autophagy in cancer cells, leading to inhibition of angiogenesis and tumor growth, while others such as laminin α2 chain (LAMA2) and lumican (LUM) are anti-autophagic [184–186].