More recently, Su et al. demonstrated a 18F-labeled RGD preferentially binds to aortic plaque in an ApoE knock out mouse model of atherosclerosis, and Golestani et al. demonstrated a good correlation between 18F-RGD-K5 uptake and intraplaque neovessels density in carotid endarterectomy specimens [7, 10]. The gene discussed is APOE; the disease is atherosclerosis.