Thus, we further identified that TIMP3 can be targeted by miR-181b-5p and miR-17-3p, implying a regulatory role of the circSMARCA5-miR-181b-5p-TIMP3 and/or circSMARCA5-miR-17-3p-TIMP3 axis involved in prostate cancer progression. Here, TIMP3 is linked to Familial prostate cancer.