THBS1 and neoplasm: Moreover, tumor size (p = 0.003), growth type (p = 0.004), histological differentiation (p < 0.0001), venous invasion (p = 0.001), THBS1 methylation in tumor tissues (p < 0.0001), or PPLF (p < 0.0001), or serum (p < 0.0001), and PLC positive (p < 0.0001) were significantly correlated with DFS of GC patients (Table 2).