CXCL8 and nasopharyngeal carcinoma: Dephosphorylation of EGFR receptor at Y-1068 and Y-1086 in nasopharyngeal carcinoma inactivates the PI3K/Akt signaling cascade, resulting in the downregulation of proangiogenic pathways, invasive proteins including VEGF, IL-6 and IL-8, and suppressing tumour cell proliferation34.