Diabetic models showed several deleterious changes such as increasing toxic end products of glycation (advance glycation end products, AGEs), expression of matrix metalloproteinases (MMP)-2 related to degradation of extracellular matrix, and hyperglycemia-induced inflammation in intervertebral disc, which promotes intervertebral disc degeneration process15–17,24–26. This evidence concerns the gene MMP2 and Hyperglycemia.