As such, aberrant IL-6 activity is implicated in diseases including systemic inflammatory response syndrome, chronic immune disorders such as crescentic glomerulonephritis, transplant rejection, and graft-versus-host disease, rheumatic diseases including rheumatoid arthritis and juvenile idiopathic arthritis, and lymphoproliferative conditions like Castleman’s disease4,8,9. This evidence concerns the gene IL6 and rheumatoid arthritis.