As the 11p15.4-11p15.5 locus is subjected to parental genomic imprinting22, we analyzed the methylation status of H19 (a non-coding RNA tumor suppressor with maternal expression), IGF2-AS (insulin-like growth factor II gene, pro-oncogenic gene expressed only from the paternal allele) and the KCNQ1OT1 imprinting centers in three LOH-positive clones compared to five LOH-negative clones. The gene discussed is H19; the disease is neoplasm.