We found that HSPCs with iCN-LOH harbor a bi-allelic paternal methylation pattern encompassing the imprinted 11p15.4-11p15.5 tumor suppressor domain, which contains the maternally expressed CDKN1C and H19 and the paternally expressed pro-oncogenic IGF2. CN-LOH-associated disomy of the methylated or unmethylated alleles led to either complete inactivation or enhanced expression of the implicated genes. Here, CDKN1C is linked to neoplasm.