LATS2 and Insulin resistance: In a second model of diet induced diabetes, we checked whether LATS2 is critical for the long-term β-cell compensatory response by subjecting 8-week-old control Rip-Cre and β-LATS2−/− mice to normal or diabetogenic high-fat/high sucrose diets (ND or HFD) for 17 weeks, which led to chronic hyperglycemia, insulin resistance as well as β-cell failure in wild-type mice14, 39.