A total of 12 P/LP variants in 10 genes were identified in the FTD cohort, including MAPT, GRN, C9orf72, CHCHD10, TBK1, OPTN, SQSTM1, VCP, SIGMAR1, and HTT, summarized in Table 2. The gene discussed is SIGMAR1; the disease is frontotemporal dementia.