In patients with PSEN1/PSEN2/APP variants, 93.9% (31/33) were defined as early-onset AD (EOAD) (AAO < 65 years)), 45.5% were APOE4-negative, 48.5% had one APOE4, and 6.0% had two copies of APOE4. This evidence concerns the gene APOE and Alzheimer disease.