RSPO3 and colorectal carcinoma: High doses of the anti-RSPO3 antibody reduced serum levels of the bone formation marker P1NP in a majority of the evaluated subjects, indicating that RSPO3 enhances bone formation also in humans (https://publications.oncomed.com/Ph-1ab-OMP-131R10-anti-RSPO3-adv-solid-tumor-prev-treat-met-CRC-2016-EORTC-NCI-AACR.pdfDownloaded 2020.11.24).