Indeed, in the reciprocal situation, in studies designed to mimic age related sarcopenia by disrupting skeletal muscle SRF expression, this resulted in atrophy, fibrosis, lipid accumulation and disturbed regeneration (18) which are all hallmarks of the DMD phenotype (19, 20, 21) further supporting their cyclical nature and mutual dependence. This evidence concerns the gene SRF and Duchenne muscular dystrophy.