MMP2 and neoplasm: Indeed, we found that MIF, CD74, and CD44, which are related to the MIF signaling pathway, and PI3K/Akt and MMP2/9 signaling-mediated regulation MIF were downregulated in the tumor tissue of rSmeg-hMIF-hIL-7-vaccinated mice (figure 2), suggesting a significant role of the anti-MIF humoral immune response by rSmeg-hMIF-hIL-7 in its anticancer effect.