rSmeg-hMIF-hIL-7 alone suppressed tumor growth and body weight change compared with PBS treatment, but the combinational treatment of rSmeg-hMIF-hIL-7 and anti-PD-L1 showed significant reduction in tumor volume and body weight change compared with rSmeg-hMIF-hIL-7 treatment alone or anti-PD-L1 alone (figure 7A and B). Here, CD274 is linked to neoplasm.