CXCR4 and neoplasm: In addition, among the surface MIF receptors, surface expression of CXCR2 and CXCR4 in M-MDSC, and CXCR4 and CXCR7 in G-MDSC were decreased in response to rSmeg-hMIF-hIL-7, indicating that rSmeg-hMIF-hIL-7 suppressed the infiltration of MDSC into tumor (figure 4B and C).