Smeg can also induce the maturation of dendritic cells better than BCG and can trigger CD8+ T cell mediated immune responses, suggesting that it has an advantage in inducing the cytotoxic T lymphocyte (CTL) response, which is necessary for cancer immunotherapy.9 10 These findings highlight the potential role of Smeg as a recombinant vaccine delivery vector for cancer immunotherapy. This evidence concerns the gene CD8A and cancer.