MAPT and Alzheimer disease: When repeating the same analysis using the three ROIs specific for different tau stages, no association was observed between tau-PET values in the hippocampal formation (Braak I/II) and global network properties in preclinical AD participants (Supplementary Results eTable 1), suggesting that using the tau-PET signal in the temporal meta-ROI is more suitable in relation to network measures than early tau-accumulation regions.