We speculate MC precursors in the ALS spinal cord could correspond to the population of small non-granular c-Kit+ cells that are found in significant numbers in the motor neuron-vascular niche of both ALS subjects and murine models, suggesting that only a portion of c-Kit+ MC precursors trafficking from blood to the spinal cord readily differentiate into typical MCs containing granules. This evidence concerns the gene KIT and amyotrophic lateral sclerosis.