The results revealed that 18 of the DMR genes were associated with addiction and obesity (ADCY3; ADCY9; ATF4; CDK5R1; CHRNB2; GABRD; GABRG3; GNB1; GNB3; GRK5; HDAC4; HDAC9; MAP2K1; PDE11A; PDE2A; PDE3A; PPP1CA; SLC6A3). This evidence concerns the gene PDE2A and obesity due to melanocortin 4 receptor deficiency.