The knowledge that WHR is an important sex-specific metric in the evaluation of weight-related disease [50], proposes the rs705379:C (NM_000446.6;c.-108C) variant and consequently high PON1 activity as a determinant for hepatic manifestations in patients affected by obesity rather than a risk factor for the onset of metabolic disease. Here, PON1 is linked to obesity due to melanocortin 4 receptor deficiency.