Therefore, patients with IL-12Rβ1 deficiency suffer from mycobacterial diseases due to IL12R and IL23R deficiencies, and chronic mucocutaneous candidiasis (CMC) due to impaired IL-23-dependent IL-17 production, while the etiology of salmonellosis like mycobacteriosis probably involves both IL12R and IL23R deficiencies given the relative rarity of salmonellosis in other MSMD etiologies [13]. Here, IL23R is linked to Mendelian susceptibility to mycobacterial diseases.