Seventeen gene mutations are involved in MSMD (IL12B, IL12RB1, IL12RB2, IL23R, JAK1, RORC, ISG15, TYK2, IRF8, SPPL2A, CYBB, IFNGR1, IFNGR2, STAT1, NEMO, TBX21, and ZNFX1) [2, 5–7]. Here, IL23R is linked to Mendelian susceptibility to mycobacterial diseases.