Dai et al. [4] and Ibe et al. [8] have failed to show any association between nesfatin-1 and HOMA-IR or HbA1c, while Sahin et al. [23], in a cohort of 54 patients with polycystic ovary syndrome (PCOS) and 48 matched controls, showed a strong positive correlation with HOMA-IR. This evidence concerns the gene NUCB2 and polycystic ovary syndrome.