A recent meta-analysis showed no statistically significant differences in circulating nesfatin-1 levels between patients with T2DM and controls (MD = − 0.04; 95% CI = − 0.32 to − 0.23), however, higher levels were noted in patients with newly diagnosed disease and lower levels in those under antidiabetic treatment [24]. Here, NUCB2 is linked to type 2 diabetes mellitus.